Executive Summary: The Brain Injury and Mechanism of Action of Hyperbaric Oxygen for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury (mTBI) (BIMA) Study

Publication Type
Journal Article
Year of Publication
2016
Authors
Weaver, LK; Chhoeu, A; Lindblad, AS; Churchill, S; Wilson, SH
Secondary
Undersea & Hyperbaric Med
Volume
43
Start Page
485
Pagination
485-490
Date Published
11/2016
Keywords
baseline; hyperbaric oxygen; mild traumatic brain injury; traumatic brain injury
Abstract
The Brain Injury and Mechanism of Action of Hyperbaric Oxygen for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury (mTBI) (BIMA) study, sponsored by the Department of Defense and held under an investigational new drug application by the Office of the Army Surgeon General, is one of the largest and most complex clinical trials of hyperbaric oxygen (HBO2) for post-concussive symptoms (PCS) in U.S. military service members. Compared to previously published HBO2 trials for PCS, this randomized, double-blinded, sham-controlled exploratory study has a longer duration of follow-up and a more comprehensive battery of assessments. These include testing of vestibular, audiologic, neuropsychological, autonomic, neurological and ocular functions; neuroimaging; sleep quality; physical examinations; and laboratory testing. The study enrolled active-duty military and veteran personnel with mild TBI sustained while on active duty who are still symptomatic three months to five years later.