A Case-Control-Study of Risk Factors for Homophiles Influenza Type B Disease in Navajo Children
Year of Publication
Wolff, M; Moulton, LH; Newcomer, W; Reid, R; Santo, SM
AM J Trop Med Hug
Analysis of Variance; Case-Control Studies; COMVAX; Haemophilus Infections; Haemophilus influenzae type b; Haemophilus Vaccines; Hepatitis B Vaccines; Indians- North American; Risk Factors; Rural Health; Vaccines-Conjugate
To understand the potential risk factors and protective factors for invasive Haemophilus influenzae type b (Hib) disease, we conducted a case-control study among Navajo children less than two years of age resident on the Navajo Nation. We analyzed household interview data for 60 cases that occurred between August 1988 and February 1991, and for 116 controls matched by age, gender, and geographic location. The Hib vaccine recipients were excluded from the analyses. Conditional logistic regression models were fit to examine many variables relating to social and environmental conditions. Risk factors determined to be important were never breast fed (odds ratio [OR] = 3.55, 95% confidence interval [CI] = 1.52, 8.26), shared care with more than one child less than two years of age (OR = 2.32, 95% CI = 0.91, 5.96); wood heating (OR = 2.14, 95% CI = 0.91, 5.05); rodents in the home (OR = 8.18, 95% CI = 0.83, 80.7); and any livestock near the home (OR = 2.18, 95% CI = 0.94, 5.04).