Post-Transplant Diabetes Mellitus in Pediatric Liver Transplantation

Publication Type
Journal Article
Year of Publication
2009
Authors
Hathout, Eba; Alonso, Estella; Anand, Ravinder; Martz, Karen; Imseis, Essam; Johnston, Joyce; Lopez, James; Chinnock, Richard; McDiarmid, Sue; The SPLIT Study Group
Secondary
Pediatr Transplant
Volume
13
Start Page
599
Pagination
599-605
Date Published
08/2009
Keywords
Adolescent; body mass index; Child; Child, Preschool; Cytomegalovirus; diabetes mellitus; Female; Humans; Immunosuppressive Agents; Infant; Infant, Newborn; Islets of Langerhans; liver transplantation; Male; Multivariate Analysis; Tacrolimus
Abstract

To determine the characteristics of pediatric liver transplant recipients who develop GI and/or PTDM, data on children undergoing their first liver transplant from the SPLIT database were analyzed (n = 1611). Recipient and donor characteristics that were evaluated included age at transplant, gender, race, primary disease, hospitalization status at transplant, BMI, recipient and donor CMV status, donor type, donor age, and primary immunosuppression. GI/PTDM was found in 214 individuals (13%) of whom 166 (78%) were diagnosed within 30 days of transplantation (early GI/PTDM). Multivariate analyses suggests that age >5 yr at transplant, hospitalization at transplant, a primary diagnosis other than BA, early steroid use, and tacrolimus use are associated with increased incidence of early GI. Routine monitoring for the development of GI and post-transplant diabetes is indicated in the short- and long-term care of children after liver transplantation.