Combination Chemotherapy for Locally Advanced Pancreatic Cancer: Equivalence to External Beam Irradiation and Implication for Future Management

Publication Type
Journal Article
Year of Publication
1983
Authors
Smith, F P; Stablein, D; Korsmeyer, S; Neefe, J; Chun, B K; Woolley, P V; Schein, P S
Secondary
J Clin Oncol
Volume
1
Start Page
413
Pagination
413-415
Date Published
07/1983
Keywords
Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycin; Mitomycins; Pancreatic Neoplasms; Radiotherapy Dosage
Abstract

Chemotherapy with 5-fluorouracil, doxorubicin, and mitomycin-C was administered to 17 patients with locally advanced pancreatic cancer. The median survival for these patients was 8 months. With a multiaxial retrospective analysis, the overall survival of this study group appears to be least equivalent to that reported with 6,000 photon rad alone or of neutrons, and compares favorably to that achieved with combined 6,000 photo rad plus 5-fluorouracil. Of 15 relapses, only 4 had presented with evidence of disseminated disease. Based upon this analysis we recommend additional studies of combination chemotherapy with radiation therapy in future prospective randomized trials.