Ambient Temperature and Risk of Cardiovascular Events At Labor and Delivery: A Case-Crossover Study

Publication Type
Journal Article
Year of Publication
2017
Authors
Ha, S; Nguyen, K; Liu, D; Mannisto, T; Nobles, C; Sherman, S; Mendola, P
Secondary
Environ Res
Volume
159
Start Page
622
Pagination
622-628
Date Published
11/2017
Keywords
Adult; Cardiovascular Diseases; Cross-Over Studies; Female; Heart Arrest; heart failure; Humans; Labor, Obstetric; Myocardial Ischemia; Pregnancy; Seasons; Stroke; Temperature; United States; Young Adult
Abstract

BACKGROUND: Extreme ambient temperatures are linked to cardiac events in the general population, but this relationship is unclear among pregnant women. We estimated the associations and attributable risk between ambient temperature and the risk of cardiovascular event at labor/delivery, and investigated whether these associations vary by maternal race/ethnicity.

METHODS: We identified 680 women with singleton deliveries affected by cardiovascular events across 12 US sites (2002-2008). Average daily temperature during the week before, delivery day, and each of the seven days before delivery was estimated for each woman. In a case-crossover analysis, exposures during these hazard periods were compared to two control periods before and after delivery using conditional logistic regression adjusted for other environmental factors.

RESULTS: During the cold season (October-April), 1°C lower during the week prior to delivery was associated with a 4% (95% CI: 1-7%) increased risk of having a labor/delivery affected by cardiovascular events including cardiac arrest and stroke. During the warm season (May-September), 1°C higher during the week prior was associated with a 7% (95% CI: 3-12%) increased risk. These risks translated to 13.4 and 23.9 excess events per 100,000 singleton deliveries during the cold and warm season, respectively. During the warm season, the risks were more pronounced on days closer to delivery and Black women appeared to be more susceptible to the same temperature increase.

CONCLUSION: Small changes in temperature appear to affect the risk of having cardiovascular events at labor/delivery. Black women had a differentially higher warm season risk. These findings merit further investigation.