Phenotypic Characterization of Eosinophilic Esophagitis in a Large Multicenter Patient Population from the Consortium for Food Allergy Research.

Publication Type
Journal Article
Year of Publication
2018
Authors
Chehade, Mirna; Jones, Stacie M; Pesek, Robbie D; Burks, A Wesley; Vickery, Brian P; Wood, Robert A; Leung, Donald Y M; Furuta, Glenn T; Fleischer, David M; Henning, Alice K; Dawson, Peter; Lindblad, Robert W; Sicherer, Scott H; Abonia, J Pablo; Sherrill, Joseph D; Sampson, Hugh A; Rothenberg, Marc E
Secondary
J Allergy Clin Immunol Pract
Volume
6
Start Page
1534
Pagination
1534-1544.e5
Date Published
09-10/2018
Keywords
Atopy; Autoimmune disease; Eosinophilic colitis; Eosinophilic esophagitis; Eosinophilic gastritis; Eosinophilic gastroenteritis; food allergy; Multisite; Proton pump inhibitor; Race; registry
Abstract

BACKGROUND: Eosinophilic esophagitis (EoE) is increasingly common, but data on phenotypic aspects are still incomplete.

OBJECTIVES: To describe the clinical, endoscopic, and histopathologic features of a large number of children and adults with EoE across the United States.

METHODS: This was a multisite single visit registry enrolling subjects aged 6 months to 65 years with EoE. Participants provided responses regarding their medical history, with verification of the diagnosis and history by the study teams.

RESULTS: A total of 705 subjects were analyzed (median [interquartile range] age at enrollment 11.2 [6.7-17.7] years, 68.2% male, 87.9% whites). Of these, 67 subjects had concurrent gastrointestinal eosinophilia, with gastric mucosa most common. An age- and race-dependent time gap was present between symptom onset and time of diagnosis (adults and whites with longer gap). Food allergy and atopic dermatitis were associated with a decrease in this gap. Symptoms varied with age (more dysphagia and food impaction in adults) and with race (more vomiting in non-whites). Esophageal rings and strictures at diagnosis were more common in adults, although esophageal eosinophilia was comparable among age groups. Concomitant allergic disease (91%), infectious/immunologic disorders (44%), neurodevelopmental disorders (30%), and failure to thrive (21%) were common. Depression/anxiety increased with age. EoE was reported in 3% of parents and 4.5% of siblings.

CONCLUSIONS: Gastrointestinal eosinophilia is present in approximately 10% of patients with EoE; the symptom-diagnosis time gap is influenced by age, race, food allergy, and atopic dermatitis; symptoms vary with race; concurrent infectious/immunologic disorders and mental health disorders are common; and the level of esophageal eosinophils is comparable in patients with and without fibrostenotic features.