Evaluation of Optimized Digital Fundus Reflex Photographs for Lens Opacities in the Age-Related Eye Disease Study 2: AREDS2 Report 7

Publication Type
Journal Article
Year of Publication
2013
Authors
Domalpally, A; Danis, RP; Chew, EY; Clemons, TE; Reed, S; SanGiovanni, JP; Ferris, FL 3rd; The Age-Related Eye Disease Study 2 Research Group
Secondary
Invest Ophthalmol Vis Sci
Volume
54
Start Page
5989
Pagination
5989-5994
Date Published
09/2013
Keywords
AREDS2; cataract; lens opacity
Abstract
{PURPOSE: We described the system for grading lens opacities using stereoscopic digital fundus reflex photographs in the Age-Related Eye Disease Study 2 (AREDS2) and compared reproducibility with the AREDS lens grading system, which used retroillumination film images. METHODS: Stereoscopic fundus reflex photographs were acquired in a standardized fashion at baseline and annually. Images were enhanced and evaluated in the red channel at a central reading center. Percentage involvement of cortical and posterior subcapsular (PSC) lens opacities within the central 5 mm diameter zone of a modified AREDS lens grid was estimated. Reproducibility was assessed for contemporaneous variability (ongoing, monthly regrade on 5% of submissions