Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010

Publication Type
Journal Article
Year of Publication
2012
Authors
Barton, FB; Rickels, MR; Alejandro, R; Hering, BJ; Wease, S; Naziruddin, B; Oberholzer, J; Odorico, JS; Garfinkel, MR; Levy, M; Pattou, F; Berney, T; Secchi, A; Messinger, S; Senior, PA; Maffi, P; Posselt, A; Stock, P; Kaufman, DB; Luo, X; Kandeel, F; Cagliero, E; Turgeon, NA; Witkowski, P; Naji, A; O'Connell, PJ; Greenbaum, C; Kudva, YC; Brayman, KL; Aull, MJ; Larsen, C; Kay, TWH; Fernandez, LA; Bellin, MD; Shapiro, AMJ
Secondary
Diabetes Care
Volume
35
Start Page
1436
Pagination
1436-1445
Date Published
07/2012
Keywords
Blood Glucose; Blood Glucose/metabolism; C-Peptide; C-Peptide/metabolism Diabetes Mellitus; Glycosylated/metabolism; Hemoglobin A; Islets of Langerhans Transplantation; Registries; Treatment Outcome; Type 1/surgery
ISBN
19355548
Abstract

OBJECTIVE

To describe trends of primary efficacy and safety outcomes of islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) from 1999 to 2010.

RESEARCH DESIGN AND METHODS

A total of 677 islet transplant-alone or islet-after-kidney recipients with type 1 diabetes in the CITR were analyzed for five primary efficacy outcomes and overall safety to identify any differences by early (1999-2002), mid (2003-2006), or recent (2007-2010) transplant era based on annual follow-up to 5 years.

RESULTS

Insulin independence at 3 years after transplant improved from 27% in the early era (1999-2002)