ABO-Blood Groups and Risk of Abdominal Aortic Aneurysm and Peripheral Obstructive Artery Disease: Two Sides of the Same Coin
Year of Publication
Mahmoodi, BK; Nijsten, M; Wijsman, J; Matthews, AG; van der Lann, L
Abdominal/blood; Aged; Aortic Aneurysm; Genetic Predisposition to Disease; Humans; Logistic Models; Odds Ratio; Peripheral Arterial Disease; Retrospective Studies; Risk Assessment
An abdominal aortic aneurysm (AAA) is a potentially fatal condition with almost half of all the deaths from ruptured AAAs occurring outside the hospital. Operative mortality rate at 30 days in acute surgery for ruptured AAA ranges as high as 30-40%. While operative mortality in elective surgery of AAAs has been reported to be as low as 2% to 6%.  Therefore, establishing risk factors for AAA play a pivotal role in identifying patients at elevated risk and candidates for AAAs screening. Extensive data indicate a strong overlap of AAA and atherosclerosis, and that classic atherosclerosis risk factors such as male sex, age, smoking, hyperlipidemia and hypertension also predispose to AAA.