Liver Transplantation in Children with Metabolic Diseases: The Studies of Pediatric Liver Transplantation Experience

Publication Type
Journal Article
Year of Publication
2010
Authors
Arnon, R; Kerkar, N; Davis, M; Anand, R; Yin, W; González-Peralta, R; The Studies of Pediatric Liver Transplantation (SPLIT) Research Group
Secondary
Pediatr Transplant
Volume
14
Start Page
796
Pagination
796-805
Date Published
09/2010
Keywords
Adolescent; Cause of Death; Child; Female; Graft Survival; Hepatic Artery; Kaplan-Meier Estimate; Kidney Diseases; liver transplantation; Male; Metabolic Diseases; Multivariate Analysis; Portal; Research NIH Extramural; Research Non-U.S. Gov
Abstract
{Metabolic diseases are the second largest indication for LT in children after BA. There are limited data on the long-term post-transplant outcome in this unique group of patients. Therefore, our aim was to assess post-liver transplant outcomes and to evaluate risk factors for mortality and graft loss in children with metabolic disorders in comparison to those with non-metabolic diagnoses. We reviewed all patients enrolled in the SPLIT registry. Between 1995 and 2008, 446 of 2997 (14.9%) children enrolled in SPLIT underwent liver transplant for metabolic diseases. One-yr and five-yr patient survival for children with metabolic diseases was 94.6% and 88.9% and for those with other diseases 90.7% and 86.1% (log-rank p = 0.05), respectively. One-yr and five-yr graft survival for children with metabolic disorders was 90.8% and 83.8%, and for those with other diseases 85.4% and 78.0% (log-rank p = 0.005), respectively. Children with metabolic diseases were less likely to experience gastrointestinal complications (5.6% vs. 10.7%)