Omega-3 Long-Chain Polynsaturated Fatty Acid Intake Inversely Associated with 12-Year Progression to Age-Related Macular Degeneration
Year of Publication
Sangiovanni, J; Agron, E; Clemons, T; Chew, E
Aged; Diet Surveys; Dietary Fats- Unsaturated; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids Omega-3; Female; Food Habits; Macular Degeneration; Male; Odds Ratio; Research NIH Extramural
Age-related macular degeneration (AMD) is a leading cause of vision loss. Age-Related Eye Disease Study (AREDS) participants reporting the highest intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFAs) were approximately half as likely as their peers reporting the lowest intake of these nutrients to have neovascular (NV) AMD at baseline or to progress across a 6-year period from bilateral drusen to central geographic atrophy (CGA). The Age-Related Eye Disease Study provides data that represent, to our knowledge, the largest longitudinal sample collected and classified with standardized methods as part of a natural history study on AMD. We now report that our baseline and 6-year findings persisted in 12-year AMD incidence models. These results are consistent with existing data.