Incidence of PTLD in Pediatric Renal Transplant Recipients Receiving Basiliximab, Calcineurin Inhibitor, Sirolimus and Steroids

Publication Type
Journal Article
Year of Publication
2008
Authors
McDonald, R; Smith, J; Ho, M; Lindblad, R; Ikle, D; Grimm, P; Wyatt, R; Arar, M; Liereman, D; Bridges, N; Harmon, W; The CCTPT Study Group
Secondary
Am J Transplant
Volume
8
Start Page
984
Pagination
984-989
Date Published
05/2008
Keywords
Adolescent; Adrenal Cortex Hormones; Adult; Antibodies-Monoclonal; Child; Cyclosporine; Double-Blind Method; Female; Immunosuppressive Agents; Infant; kidney transplantation; Lymphoproliferative Disorders; Multivariate Analysis; Postoperative Complication
ISBN
16006143
Abstract
{Pediatric renal transplant recipients were enrolled in a multicenter, randomized, double-blind trial of steroid withdrawal. Subjects received basiliximab, calcineurin inhibitor, sirolimus and steroids. Of 274 subjects enrolled, 19 (6.9%) subjects developed posttransplant lymphoproliferative disorder (PTLD). The relative hazard (RH) for PTLD was 5.3-fold higher in children aged < or =5 versus those >12 years (p = 0.0017). EBV seronegative subjects had a 4.7-fold higher RH compared to EBV positive subjects (p = 0.02). Among EBV donor+/recipient- (D+/R-) subjects, the RH increased by 6.1-fold (p = 0.0001). In a multivariate model, risk factors included recipient age < or =5 years (RH 3.2, 95% CI: 1.1-9.6