Randomized Cinical Trial of Vitamin E in the Treatment of Uveitis-Associated Macular Edema
Year of Publication
Nussenblatt, RB; Kim, J; Thompson, DJS; Davis, MD; Chew, E; Ferris, FL; Buggage, RR
Am J Ophthalmol
Adult; Aged; Child; Double-Blind Method; Female; macular edema; Male; Middle Aged; retina; Uveitis; visual acuity; Vitamin E
PURPOSE: To investigate whether high-dose alpha-tocopherol (vitamin E) could reduce vision loss and retinal thickening associated with uveitis-associated cystoid macular edema. DESIGN: A double-masked, randomized study. METHODS: Uveitis patients with macular edema seen at the NIH were randomized and received either 1600 IU/day of vitamin E or placebo for 4 months. Visual acuity and retinal thickening were collected for the efficacy and the safety of the high dose of vitamin E. RESULTS: Changes in visual acuity and retinal thickening. CONCLUSIONS: Four-month oral supplementation with 1600 IU/d of vitamin E had no apparent effect on uveitis-associated macular edema or visual acuity in this small study.