Folic Acid and Zinc Supplementation Trial (FAZST)

Among healthy couples trying to conceive, fewer than 20% get pregnant each month. Part of this low pregnancy success rate could be due to insufficient intake of two micronutrients, folic acid and zinc, which are fundamental to the process of sperm development and several aspects of reproduction. Available data suggest that folic acid and zinc supplementation in men may improve the chances of becoming pregnant. This is of particular interest since folic acid and zinc are widely available at low cost. 

We are enrolling 2400 couples seeking help with their fertility challenges into a clinical trial to assess the effects of a special formulation of folic acid and zinc, provided as a dietary supplement for the male partner, on semen quality and pregnancy rates. This study is being conducted at several clinics in collaboration with the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

Male partners will be randomized equally (1:1) to either active study supplement formulation or matching placebo.  Study duration is 6 months.


Please click here for a Utah study brochure

Please click here for a Iowa study brochure


Please contact the FAZST Research Staff to see if you and your partner qualify to participate.


FAZST Annual Study Newsletters

Volume 1 - February 2015

Volume 2 - February 2016

Volume 3 - May 2017