About FAZST

 

  • A brief description of FAZST
  • What is the primary objective of FAZST?
  • Can I participate?
  • What will I need to do if I join FAZST?
  • Are there risks?
  • Are there any potential benefits?
  • Will I be reimbursed?

 

 

A brief description of FAZST

Available information shows that folic acid and zinc may improve pregnancy outcomes and semen quality when taken by male partners among couples trying to become pregnant. Folic acid and zinc appear to be safe and have few side effects. In this clinical trial, we will study the effects of folic acid and zinc on pregnancy outcomes and semen quality.

 

What is the primary objective of FAZST?

The primary objective of the study is to assess whether folic acid and zinc supplementation in males improves semen quality and fertility treatment outcomes (i.e., live birth rate) among couples seeking fertility treatment. 

 

Can I participate?

If you are having difficulty becoming pregnant, you may qualify for this very important study. Please contact us.

 

What will I need to do if I join FAZST?

The level of participation is different for men and women in FAZST.

 

Male participants will:

  • Meet with a research nurse every other month for six months (4 total visits).
  • Answer questions about your past and present medical and reproductive history.
  • Have simple measurements taken on you such as weight and height.
  • Provide a small amount of your blood, semen, saliva, and urine at your visits.
  • Take a daily pill that may contain either folic acid and zinc or placebo.
  • Complete a short journal, which we will provide, for the six month study duration.

 

Female participants will:

  • Meet with a research nurse at baseline.
  • Answer questions about your past and present medical and reproductive history.
  • Have simple measurements taken on you such as weight and height.
  • Provide a small amount of your blood, saliva, and urine at your initial study visit.
  • Complete a monthly questionnaire online

 

Are there risks?

  • There are small risks, such as pain and bruising from the blood draw.
  • There are no known risks to you of folic acid and zinc in becoming pregnant.
  • If you have any side-effects, we will discuss the problem with you and act appropriately.

 

Are there any potential benefits?

 Close medical evaluations and additional semen analyses.

 

Will I be reimbursed?

You will be compensated for your study visits.

 

 

Folic acid, zinc, and semen

 

Infertility affects 10 to 15% of couples attempting to conceive. Two micronutrients fundamental to the process of creating sperm, folate and zinc, are of particular interest as they offer a potential low cost and widely available treatment. Though the evidence has been inconsistent, small randomized trials and observational studies show that folate and zinc have biologically plausible effects on spermatogenesis and improved semen parameters. These results support the potential benefits of folate on spermatogenesis, and suggest that supplementation with folate and zinc may improve semen quality, and perhaps, assisted reproductive technology (ART) outcomes.